Gene
msh3
- ID
- ZDB-GENE-060526-307
- Name
- mutS homolog 3 (E. coli)
- Symbol
- msh3 Nomenclature History
- Previous Names
-
- si:dkey-56d12.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to contribute to mismatched DNA binding activity. Predicted to be involved in DNA metabolic process and positive regulation of helicase activity. Predicted to localize to MutSbeta complex. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; and familial adenomatous polyposis 4. Orthologous to human MSH3 (mutS homolog 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| endometrial cancer | Alliance | Endometrial carcinoma, somatic | 608089 |
| familial adenomatous polyposis 4 | Alliance | Familial adenomatous polyposis 4 | 617100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| Domain | IPR007695 | DNA mismatch repair protein MutS-like, N-terminal |
| Domain | IPR007696 | DNA mismatch repair protein MutS, core |
| Domain | IPR007860 | DNA mismatch repair protein MutS, connector domain |
| Domain | IPR007861 | DNA mismatch repair protein MutS, clamp |
| Family | IPR017261 | DNA mismatch repair protein MutS/MSH |
| Homologous_superfamily | IPR016151 | DNA mismatch repair protein MutS, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
| Homologous_superfamily | IPR036678 | MutS, connector domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair protein MutS, clamp | DNA mismatch repair protein MutS, connector domain | DNA mismatch repair protein MutS, core | DNA mismatch repair protein MutS, core domain superfamily | DNA mismatch repair protein MutS, C-terminal | DNA mismatch repair protein MutS-like, N-terminal | DNA mismatch repair protein MutS/MSH | DNA mismatch repair protein MutS, N-terminal | MutS, connector domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B2S9
|
1087 | ||||||||||
|
UniProtKB:A0A8M6Z0M9
|
736 | ||||||||||
|
UniProtKB:A2CEA8
|
1083 | ||||||||||
|
UniProtKB:A0A288CFS8
|
1085 |
Interactions and Pathways
No data available
Plasmids
No data available