Gene

msh3

ID
ZDB-GENE-060526-307
Name
mutS homolog 3 (E. coli)
Symbol
msh3 Nomenclature History
Previous Names
  • si:dkey-56d12.1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in mismatch repair; mitotic recombination; and somatic recombination of immunoglobulin gene segments. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With msh3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
endometrial cancer Alliance Endometrial carcinoma, somatic 608089
familial adenomatous polyposis 4 Alliance Familial adenomatous polyposis 4 617100
Associated With msh3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000432 DNA mismatch repair protein MutS, C-terminal
Domain IPR007695 DNA mismatch repair protein MutS-like, N-terminal
Domain IPR007696 DNA mismatch repair protein MutS, core
Domain IPR007860 DNA mismatch repair protein MutS, connector domain
Domain IPR007861 DNA mismatch repair protein MutS, clamp
Family IPR017261 DNA mismatch repair protein MutS/MSH
Family IPR045076 DNA mismatch repair MutS
Homologous_superfamily IPR016151 DNA mismatch repair protein MutS, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036187 DNA mismatch repair protein MutS, core domain superfamily
Homologous_superfamily IPR036678 MutS, connector domain superfamily
Domain Details Per Protein
Protein Additional Resources Length DNA mismatch repair MutS DNA mismatch repair protein MutS, clamp DNA mismatch repair protein MutS, connector domain DNA mismatch repair protein MutS, core DNA mismatch repair protein MutS, core domain superfamily DNA mismatch repair protein MutS, C-terminal DNA mismatch repair protein MutS-like, N-terminal DNA mismatch repair protein MutS/MSH DNA mismatch repair protein MutS, N-terminal MutS, connector domain superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M3B2S9 InterPro 1087
UniProtKB:A0A8M6Z0M9 InterPro 736
UniProtKB:A2CEA8 InterPro 1083
UniProtKB:A0A288CFS8 InterPro 1085
UniProtKB:A0AB32TR81 InterPro 970
UniProtKB:A0AB32TVL8 InterPro 1084
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA msh3-201 (1)
Ensembl
Ensembl 4,974 nt
ZFIN BLAST
mRNA msh3-202 (1)
Ensembl
Ensembl 4,010 nt
ZFIN BLAST
mRNA msh3-203 (1)
Ensembl
Ensembl 3,252 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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