Gene
osbp2b
- ID
- ZDB-GENE-060526-3
- Name
- oxysterol binding protein 2b
- Symbol
- osbp2b Nomenclature History
- Previous Names
-
- si:ch211-106a19.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol binding activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in telencephalon. Orthologous to human OSBP2 (oxysterol binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029076Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20410 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33593 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018494 | Oxysterol-binding protein, conserved site |
| Domain | IPR001849 | Pleckstrin homology domain |
| Family | IPR000648 | Oxysterol-binding protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR037239 | Oxysterol-binding protein superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Oxysterol-binding protein | Oxysterol-binding protein, conserved site | Oxysterol-binding protein superfamily | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A2BEG1 | InterPro | 808 | |||||
| UniProtKB:A0A8M9PXS1 | InterPro | 463 | |||||
| UniProtKB:A0A8M3AS31 | InterPro | 555 | |||||
| UniProtKB:A0A8M9Q8S0 | InterPro | 822 | |||||
| UniProtKB:A0A8M9PKA3 | InterPro | 708 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-106a19.1-201
(1)
|
Ensembl | 2,530 nt | ||
| mRNA |
si:ch211-106a19.1-204
(1)
|
Ensembl | 745 nt | ||
| ncRNA |
si:ch211-106a19.1-002
(1)
|
Ensembl | 670 nt | ||
| ncRNA |
si:ch211-106a19.1-004
(1)
|
Ensembl | 434 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122748 (1) | 2427 nt | ||
| Genomic | GenBank:BX005447 (1) | 283185 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q8S0 (1) | 822 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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