Gene
srgap3
- ID
- ZDB-GENE-060524-4
- Name
- SLIT-ROBO Rho GTPase activating protein 3
- Symbol
- srgap3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have Rac GTPase binding activity. Predicted to be involved in negative regulation of cell migration. Predicted to localize to cytoplasm. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from van Dam et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001060 | FCH domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR031160 | F-BAR domain |
| Domain | IPR035648 | srGAP1/2/3, SH3 domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH3 domain | SH3-like domain superfamily | srGAP1/2/3, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IAE2
|
1094 | ||||||||
|
UniProtKB:E7EYC8
|
1070 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
srgap3-201
(1)
|
Havana | 5100 nt | |
| ncRNA |
srgap3-002
(1)
|
Havana | 881 nt | |
| ncRNA |
srgap3-003
(1)
|
Havana | 468 nt | |
| ncRNA |
srgap3-004
(1)
|
Havana | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available