Gene
rims2b
- ID
- ZDB-GENE-060503-893
- Name
- regulating synaptic membrane exocytosis 2b
- Symbol
- rims2b Nomenclature History
- Previous Names
-
- si:ch211-95i5.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in regulation of synaptic vesicle exocytosis; synaptic vesicle docking; and synaptic vesicle priming. Predicted to act upstream of or within exocytosis and intracellular protein transport. Predicted to be located in membrane and synapse. Predicted to be active in presynaptic active zone cytoplasmic component and presynaptic membrane. Orthologous to human RIMS2 (regulating synaptic membrane exocytosis 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028001Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028002Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23489 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36810 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cone-rod synaptic disorder syndrome, congenital nonprogressive | 618970 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR010911 | Rab-binding domain |
| Domain | IPR017455 | Zinc finger, FYVE-related |
| Domain | IPR054386 | RIM, zinc finger |
| Family | IPR039032 | Rim-like |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | PDZ domain | PDZ superfamily | Rab-binding domain | Rim-like | RIM, zinc finger | Zinc finger, FYVE/PHD-type | Zinc finger, FYVE-related | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PSB0 | InterPro | 1846 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rims2b-201
(1)
|
Ensembl | 3,164 nt | ||
| mRNA |
rims2b-203
(1)
|
Ensembl | 679 nt | ||
| mRNA |
rims2b-204
(1)
|
Ensembl | 482 nt | ||
| ncRNA |
rims2b-005
(1)
|
Ensembl | 468 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-95I5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021468295 (1) | 7548 nt | ||
| Genomic | GenBank:AL844521 (1) | 213269 nt | ||
| Polypeptide | UniProtKB:A0A8M9PSB0 (1) | 1846 aa |
- Awasthi, N., Ward, A.C., Liongue, C. (2023) Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth. Frontiers in bioscience (Landmark edition). 28:187187
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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