Gene
egln2
- ID
- ZDB-GENE-060503-757
- Name
- egl-9 family hypoxia-inducible factor 2
- Symbol
- egln2 Nomenclature History
- Previous Names
-
- Hif-p4H-1 (1)
- si:ch211-113p18.4
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and regulation of neuron apoptotic process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Hyvarinen et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Hypoxia-inducible factor prolyl hydroxylases | Oxoglutarate/iron-dependent dioxygenase domain | Prolyl 4-hydroxylase, alpha subunit | Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain |
|---|---|---|---|---|---|
|
UniProtKB:E7F8S1
|
464 |
Interactions and Pathways
No data available
Plasmids
No data available