Gene
omd
- ID
- ZDB-GENE-060503-756
- Name
- osteomodulin
- Symbol
- omd Nomenclature History
- Previous Names
-
- sb:eu895
- si:ch211-103f16.5
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human OMD (osteomodulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu895 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43777 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Small Leucine-Rich Proteoglycans |
|---|---|---|---|---|---|---|---|
| UniProtKB:F6NL91 | InterPro | 401 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-103F16 | ZFIN Curated Data | |
| Encodes | EST | eu895 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017353401 (1) | |||
| Genomic | GenBank:BX908397 (1) | 87359 nt | ||
| Polypeptide | UniProtKB:F6NL91 (1) | 401 aa |
- Raman, R., Antony, M., Nivelle, R., Lavergne, A., Zappia, J., Guerrero-Limón, G., Caetano da Silva, C., Kumari, P., Sojan, J.M., Degueldre, C., Bahri, M.A., Ostertag, A., Collet, C., Cohen-Solal, M., Plenevaux, A., Henrotin, Y., Renn, J., Muller, M. (2024) The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis. Biomolecules. 14(2):
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Zappia, J., Tong, Q., Van der Cruyssen, R., Cornelis, F.M.F., Lambert, C., Pinto Coelho, T., Grisart, J., Kague, E., Lories, R.J., Muller, M., Elewaut, D., Hammond, C.L., Sanchez, C., Henrotin, Y. (2023) Osteomodulin downregulation is associated with osteoarthritis development. Bone research. 11:4949
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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