Gene

grhl2b

ID

ZDB-GENE-060503-719

Name

grainyhead-like transcription factor 2b

Symbol

grhl2b Nomenclature History

Previous Names

grhl2
si:dkey-21k18.2

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Exhibits transcription regulatory region DNA binding activity. Involved in apoptotic process involved in morphogenesis; inner ear development; and midbrain-hindbrain boundary morphogenesis. Predicted to localize to nucleus. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy. Is expressed in several structures, including anterior axial hypoblast; midbrain hindbrain boundary neural rod; neurogenic placode; optic vesicle; and posterior lateral line system. Orthologous to human GRHL2 (grainyhead like transcription factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grhl2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 28	Alliance	Deafness, autosomal dominant 28	608641
posterior polymorphous corneal dystrophy 4	Alliance	Corneal dystrophy, posterior polymorphous, 4	618031
		Ectodermal dysplasia/short stature syndrome	616029

Associated With grhl2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
autosomal dominant nonsyndromic deafness	grhl2b^{tsu086Gt/tsu086Gt} (AB)	standard conditions	Han et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007604	CP2 transcription factor
Family	IPR040167	Transcription factor CP2-like

Domain Details Per Protein

Protein	Length	CP2 transcription factor	Transcription factor CP2-like
UniProtKB:F7VJQ5 InterPro	601
UniProtKB:A0A2R8QAV0 InterPro	554

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	grhl2b-201 (1) Ensembl	Ensembl		3,699 nt	Select Tool
mRNA	grhl2b-202 (1) Ensembl	Ensembl		1,786 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations