Gene

grhl2b

ID
ZDB-GENE-060503-719
Name
grainyhead-like transcription factor 2b
Symbol
grhl2b Nomenclature History
Previous Names
  • grhl2
  • si:dkey-21k18.2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in apoptotic process involved in morphogenesis; inner ear development; and midbrain-hindbrain boundary morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including anterior axial hypoblast; midbrain hindbrain boundary neural rod; neurogenic placode; optic vesicle; and posterior lateral line system. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grhl2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 28 Alliance Deafness, autosomal dominant 28 608641
posterior polymorphous corneal dystrophy 4 Alliance Corneal dystrophy, posterior polymorphous, 4 618031
Ectodermal dysplasia/short stature syndrome 616029
Associated With grhl2b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007604 CP2 transcription factor
Domain Details Per Protein
Protein Length CP2 transcription factor
UniProtKB:F7VJQ5 601
UniProtKB:A0A2R8QAV0 554
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations