Gene
thsd7aa
- ID
- ZDB-GENE-060503-709
- Name
- thrombospondin, type I, domain containing 7Aa
- Symbol
- thsd7aa Nomenclature History
- Previous Names
-
- thsd7a
- si:dkey-12h3.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including axon extension; glomerular filtration; and podocyte development. Predicted to be located in cell projection and membrane. Predicted to be active in plasma membrane. Is expressed in nervous system; neural tube; and pectoral fin. Orthologous to human THSD7A (thrombospondin type 1 domain containing 7A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020806Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8458 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15977 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36889 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39256 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-thsd7aa | N/A | (2) |
| MO2-thsd7aa | N/A | (2) |
| MO3-thsd7aa | N/A | Tomas et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Spondin-like TSP1 domain | Spondin/Thrombospondin type-1 domain-containing | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IT78 | InterPro | 1684 | ||||
| UniProtKB:A0A8M2B6E3 | InterPro | 1686 | ||||
| UniProtKB:A0A8M3AKC5 | InterPro | 1702 | ||||
| UniProtKB:A7MBS7 | InterPro | 1686 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
thsd7aa-201
(1)
|
Ensembl | 4,904 nt | ||
| mRNA |
thsd7aa-202
(1)
|
Ensembl | 5,424 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(thsd7aa:GFP) |
|
| 1 | Liu et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-12H3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-108G22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122760 (1) | 5424 nt | ||
| Genomic | GenBank:CR381594 (2) | 182645 nt | ||
| Polypeptide | UniProtKB:A0A8M3AKC5 (1) | 1702 aa |
- Shin, K., Rodriguez-Parks, A., Kim, C., Silaban, I.M., Xia, Y., Sun, J., Dong, C., Keles, S., Wang, J., Cao, J., Kang, J. (2024) Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nature communications. 15:96669666
- Tomas, N.M., Meyer-Schwesinger, C., von Spiegel, H., Kotb, A.M., Zahner, G., Hoxha, E., Helmchen, U., Endlich, N., Koch-Nolte, F., Stahl, R.A.K. (2017) A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy. Journal of the American Society of Nephrology : JASN. 28(11):3262-3277
- Liu, L.Y., Lin, M.H., Lai, Z.Y., Jiang, J.P., Huang, Y.C., Jao, L.E., Chuang, Y.J. (2016) Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. Journal of Biomedical Science. 23:59
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, C.H., Chen, I.H., Kuo, M.W., Su, P.T., Lai, Z.Y., Wang, C.H., Huang, W.C., Hoffman, J., Kuo, C.J., You, M.S., and Chuang, Y.J. (2011) Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(6):1412-1421
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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