Gene
cica
- ID
- ZDB-GENE-060503-700
- Name
- capicua transcriptional repressor a
- Symbol
- cica Nomenclature History
- Previous Names
-
- si:ch211-39e15.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in head and telencephalon. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1539 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12496 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13191 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39226 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43212 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45654 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cica | (2) | |
| CRISPR2-cica | (2) | |
| CRISPR3-cica | (2) | |
| CRISPR4-cica | (2) | |
| CRISPR5-cica | (2) | |
| CRISPR6-cica | (2) | |
| CRISPR7-cica | (2) | |
| CRISPR8-cica | (2) | |
| MO1-cica | N/A | Huang et al., 2013 |
| MO2-cica | N/A | Huang et al., 2013 |
1 - 10 of 10
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 45 | Alliance | Intellectual developmental disorder, autosomal dominant 45 | 617600 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cell Cycle and Developmental Transcription Regulators | Domain of unknown function DUF4819 | High mobility group box domain | High mobility group box domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RP12 | InterPro | 2440 | ||||
| UniProtKB:A0A8M3AJY9 | InterPro | 2293 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-39E15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-272D23 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003200533 (1) | 10063 nt | ||
| Genomic | GenBank:BX004874 (1) | 165154 nt | ||
| Polypeptide | UniProtKB:A0A8M1RP12 (1) | 2440 aa |
- Ladam, F., Stanney, W., Donaldson, I.J., Yildiz, O., Bobola, N., Sagerström, C.G. (2018) TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. eLIFE. 7
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Chen, T., Zhou, L., Yuan, Y., Fang, Y., Guo, Y., Huang, H., Zhou, Q., Lv, X. (2014) Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic. Development genes and evolution. 224(4-6):261-8
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
1 - 7 of 7
Show