Gene
rspo2
- ID
- ZDB-GENE-060503-667
- Name
- R-spondin 2
- Symbol
- rspo2 Nomenclature History
- Previous Names
-
- si:ch211-149p10.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable BMP receptor binding activity. Acts upstream of or within several processes, including cranial skeletal system development; fin development; and regulation of odontogenesis. Predicted to be active in extracellular space. Is expressed in several structures, including brain; cranium; fin; forebrain midbrain boundary neural rod; and inner dental epithelium. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| js201 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| js202 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| sa2871 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11926 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rspo2 | Alhazmi et al., 2021 | |
| CRISPR2-rspo2 | Alhazmi et al., 2021 | |
| CRISPR3-rspo2 | Alhazmi et al., 2021 | |
| CRISPR4-rspo2 | Alhazmi et al., 2021 | |
| TALEN1-rspo2 | (5) | |
| TALEN2-rspo2 | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| tetraamelia syndrome 2 | Alliance | Tetraamelia syndrome 2 | 618021 |
| ?Humerofemoral hypoplasia with radiotibial ray deficiency | 618022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR043601 | R-spondin, Fu-CRD domain |
| Domain | IPR044004 | Spondin-like TSP1 domain |
| Family | IPR051514 | R-spondin domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | R-spondin domain-containing protein | R-spondin, Fu-CRD domain | Spondin-like TSP1 domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5C9 | InterPro |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149P10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001281990 (1) | |||
| Genomic | GenBank:BX294114 (1) | 195651 nt | ||
| Polypeptide | UniProtKB:F1Q5C9 (2) |
- Iwasaki, M., Kawakami, K., Wada, H. (2022) Remodeling of the hyomandibular skeleton and facial nerve positioning during embryonic and postembryonic development of teleost fish. Developmental Biology. 489:134-145
- Alhazmi, N., Carroll, S.H., Kawasaki, K., Woronowicz, K.C., Hallett, S.A., Macias Trevino, C., Li, E.B., Baron, R., Gori, F., Yelick, P.C., Harris, M.P., Liao, E.C. (2021) Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. Scientific Reports. 11:5871
- Iwasaki, M., Yokoi, H., Suzuki, T., Kawakami, K., Wada, H. (2020) Development of the anterior lateral line system through local tissue-tissue interactions in the zebrafish head. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(12):1440-1454
- Lan, Y., Pan, H., Li, C., Banks, K.M., Sam, J., Ding, B., Elemento, O., Goll, M.G., Evans, T. (2019) TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Reports. 26:720-732.e4
- Wang, B., Yang, F., Li, R., Li, X., Wu, X., Sun, Z., Zhai, J., He, Y., Qi, J. (2018) Functional characterization of Cynoglossus semilaevis R-spondin2 and its role in muscle development during embryogenesis. Genes & genetic systems. 93(5):181-190
- Massarsky, A., Prasad, G.L., Di Giulio, R.T. (2017) Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio). Toxicology and applied pharmacology. 339:85-96
- Zhang, H., Yao, Y., Chen, Y., Yue, C., Chen, J., Tong, J., Jiang, Y., Chen, T. (2016) Crosstalk between AhR and wnt/β-catenin signal pathways in the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Toxicology. 355-356:31-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wincent, E., Stegeman, J.J., Jönsson, M.E. (2015) Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Toxicology and applied pharmacology. 284(2):163-79
- Tatsumi, Y., Takeda, M., Matsuda, M., Suzuki, T., Yokoi, H. (2014) TALEN-mediated mutagenesis in zebrafish reveals a role for r-spondin 2 in fin ray and vertebral development. FEBS letters. 588(24):4543-50
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