Gene
gabbr2
- ID
- ZDB-GENE-060503-620
- Name
- gamma-aminobutyric acid (GABA) B receptor, 2
- Symbol
- gabbr2 Nomenclature History
- Previous Names
-
- si:dkey-190l1.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gabbr2 | Guo et al., 2022 | |
| CRISPR2-gabbr2 | LaCoursiere et al., 2024 | |
| CRISPR3-gabbr2 | LaCoursiere et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 59 | Alliance | Developmental and epileptic encephalopathy 59 | 617904 |
| Neurodevelopmental disorder with poor language and loss of hand skills | 617903 | ||
| {Nicotine dependence, protection against} | 188890 | ||
| {Nicotine dependence, susceptibility to} | 188890 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017979 | GPCR, family 3, conserved site |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR017978 | GPCR family 3, C-terminal |
| Domain | IPR041689 | Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain |
| Family | IPR000337 | GPCR, family 3 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain | GPCR, family 3 | GPCR, family 3, conserved site | GPCR family 3, C-terminal | GPCR family 3, GABA-B receptor | GPCR family 3, gamma-aminobutyric acid receptor, type B2 | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LUN9 | InterPro | 935 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabbr2-201
(1)
|
Ensembl | 2,808 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-9N13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-10D14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-124E6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-226I21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-266K5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-190L1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144043 (1) | |||
| Genomic | GenBank:BX649545 (1) | 169802 nt | ||
| Polypeptide | UniProtKB:Q1LUN9 (1) | 935 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Li, Y., Zhang, L., Mao, M., He, L., Wang, T., Pan, Y., Zhao, X., Li, Z., Mu, X., Qian, Y., Qiu, J. (2023) Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. iScience. 26:106744106744
- Guo, S., Gao, G., Zhang, C., Peng, G. (2022) Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish. Veterinary sciences. 9(2):
- Manchanda, A., Bonventre, J.A., Bugel, S.M., Chatterjee, P., Tanguay, R., Johnson, C.P. (2021) Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking. Molecular biology of the cell. 32(14):1293-1305
- Probst, J., Kölker, S., Okun, J.G., Kumar, A., Gursky, E., Posset, R., Hoffmann, G.F., Peravali, R., Zielonka, M. (2020) Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. Experimental neurology. 331:113330
- Shen, C., Zhou, Y., Tang, C., He, C., Zuo, Z. (2020) Developmental exposure to mepanipyrim induces locomotor hyperactivity in zebrafish (Danio rerio) larvae. Chemosphere. 256:127106
- Samarut, É., Swaminathan, A., Riché, R., Liao, M., Hassan-Abdi, R., Renault, S., Allard, M., Dufour, L., Cossette, P., Soussi-Yanicostas, N., Drapeau, P. (2018) γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment. Epilepsia. 59(11):2061-2074
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cocco, A., Carolina Rönnberg, A.M., Jin, Z., André, G.I., Vossen, L.E., Bhandage, A.K., Thörnqvist, P.O., Birnir, B., Winberg, S. (2017) Characterisation of the γ-aminobutyric acid signalling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription quantitative polymerase chain reaction. Neuroscience. 343:300-321
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