Gene
pln1
- ID
- ZDB-GENE-060503-603
- Name
- phospholamban 1
- Symbol
- pln1 Nomenclature History
- Previous Names
-
- PLB (1)
- pln
- si:ch211-260o22.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable ATPase inhibitor activity. Predicted to be involved in negative regulation of calcium ion import into sarcoplasmic reticulum and negative regulation of heart rate. Predicted to act upstream of or within regulation of ATPase-coupled calcium transmembrane transporter activity. Predicted to be located in mitochondrial membrane and sarcoplasmic reticulum membrane. Predicted to be active in membrane and sarcoplasmic reticulum. Is expressed in heart. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1P | Alliance | Cardiomyopathy, dilated, 1P | 609909 |
| hypertrophic cardiomyopathy 18 | Alliance | Cardiomyopathy, hypertrophic, 18 | 613874 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR005984 | Phospholamban |
Domain Details Per Protein
| Protein | Length | Phospholamban |
|---|---|---|
|
UniProtKB:A0A8M1P2H4
|
57 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available