Gene
scin
- ID
- ZDB-GENE-060503-6
- Name
- scinderin
- Symbol
- scin Nomenclature History
- Previous Names
-
- si:ch211-134n17.3
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in anchoring junction and podosome. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in brain; cornea; heart; and lens. Orthologous to human SCIN (scinderin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Jia et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | ADF-H/Gelsolin-like domain superfamily | Gelsolin-like domain | Villin/Gelsolin |
---|---|---|---|---|---|
UniProtKB:Q1LYK7 | InterPro | 733 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-134N17 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045118 (1) | 2249 nt | ||
Genomic | GenBank:BX572629 (1) | 170971 nt | ||
Polypeptide | UniProtKB:Q1LYK7 (1) | 733 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Jia, S., Omelchenko, M., Garland, D., Vasiliou, V., Kanungo, J., Spencer, M., Wolf, Y., Koonin, E., and Piatigorsky, J. (2007) Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(12):3318-3328
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