Gene

scin

ID
ZDB-GENE-060503-6
Name
scinderin
Symbol
scin Nomenclature History
Previous Names
  • si:ch211-134n17.3
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in anchoring junction and podosome. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in brain; cornea; heart; and lens. Orthologous to human SCIN (scinderin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Jia et al., 2007
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa36864Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sa39252Allele with one point mutationUnknownSplice SiteENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
1 - 2 of 2
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Sequence Targeting Reagents
No data available
Human Disease
Associated With scin Human Ortholog
No data available
Associated With scin Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007123 Gelsolin-like domain
Family IPR007122 Villin/Gelsolin
Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length ADF-H/Gelsolin-like domain superfamily Gelsolin-like domain Villin/Gelsolin
UniProtKB:Q1LYK7 InterPro 733
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA scin-201 (1)
Ensembl
Ensembl 2,249 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-134N17ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001045118 (1)2249 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:BX572629 (1)170971 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:Q1LYK7 (1)733 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSCIN7
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseScin12
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
TSV
1 - 2 of 2
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