ZFIN is now using GRCz12tu for Genomic Data
Gene
slc5a5
- ID
- ZDB-GENE-060503-585
- Name
- solute carrier family 5 member 5
- Symbol
- slc5a5 Nomenclature History
- Previous Names
-
- NIS (1)
- si:ch211-200a16.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to be located in plasma membrane. Is expressed in brain; ovary; pharynx; thyroid follicle; and thyroid primordium. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 1 | Alliance | Thyroid dyshormonogenesis 1 | 274400 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium/glucose symporter superfamily | Sodium/solute symporter | Sodium:Solute Symporter (SSF) |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q9Q5 | InterPro | 438 | |||
| UniProtKB:A4IG60 | InterPro | 601 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc5a5-201
(1)
|
Ensembl | 1,698 nt | ||
| mRNA |
slc5a5-202
(1)
|
Ensembl | 2,029 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers