Gene
slc9a3.1
- ID
- ZDB-GENE-060503-545
- Name
- solute carrier family 9 member A3, tandem duplicate 1
- Symbol
- slc9a3.1 Nomenclature History
- Previous Names
-
- nhe3a (1)
- si:dkey-3n22.4
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within proton transmembrane transport; regulation of pH; and sodium ion transport. Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in apical plasma membrane and brush border membrane. Is expressed in kidney. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Yan et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital secretory sodium diarrhea 8 | Alliance | Diarrhea 8, secretory sodium, congenital | 616868 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation/H+ exchanger, CPA1 family | Cation/H+ exchanger, transmembrane domain | Na+/H+ exchanger | Na+/H+ exchanger, isoforms 3/5 |
|---|---|---|---|---|---|---|
| UniProtKB:B7ZVJ6 | InterPro | 832 | ||||
| UniProtKB:A9XPA1 | InterPro | 832 | ||||
| UniProtKB:A0AB32T9J1 | InterPro | 831 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
slc9a3.1-201
(1)
|
Ensembl | 3,645 nt | ||
| mRNA |
slc9a3.1-202
(1)
|
Ensembl | 3,398 nt |
Interactions and Pathways
No data available
Plasmids
No data available