Gene
gpcpd1
- ID
- ZDB-GENE-060503-472
- Name
- glycerophosphocholine phosphodiesterase 1
- Symbol
- gpcpd1 Nomenclature History
- Previous Names
-
- si:rp71-81o21.1 (1)
- zgc:103717
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable glycerophosphocholine phosphodiesterase activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to act upstream of or within lipid metabolic process. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103717 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013906Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021683Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12862 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13354 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23799 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23800 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002044 | Carbohydrate binding module family 20 |
| Domain | IPR030395 | Glycerophosphodiester phosphodiesterase domain |
| Domain | IPR034839 | Glycerophosphocholine phosphodiesterase GPCPD1, CBM20 domain |
| Family | IPR051578 | Glycerophosphodiester Phosphodiesterase |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Carbohydrate-binding-like fold | Carbohydrate binding module family 20 | Glycerophosphocholine phosphodiesterase GPCPD1, CBM20 domain | Glycerophosphodiester Phosphodiesterase | Glycerophosphodiester phosphodiesterase domain | Immunoglobulin-like fold | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PSM9 | InterPro | 701 | |||||||
| UniProtKB:A0A8M9PHA0 | InterPro | 727 | |||||||
| UniProtKB:Q1LVM1 | InterPro | 666 | |||||||
| UniProtKB:A0A8M3AWH0 | InterPro | 592 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gpcpd1-201
(1)
|
Ensembl | 2,366 nt | ||
| mRNA |
gpcpd1-202
(1)
|
Ensembl | 2,001 nt | ||
| mRNA |
gpcpd1-203
(1)
|
Ensembl | 345 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-355E4 | ZFIN Curated Data | |
| Contained in | BAC | RP71-81O21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103717 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110523 (1) | 2001 nt | ||
| Genomic | GenBank:CU075930 (1) | 88655 nt | ||
| Polypeptide | UniProtKB:A0A8M9PHA0 (1) | 727 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I. (2013) The BH3-Only SNARE BNip1 Mediates Photoreceptor Apoptosis in Response to Vesicular Fusion Defects. Developmental Cell. 25(4):374-387
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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