Gene

plch1

ID

ZDB-GENE-060503-398

Name

phospholipase C, eta 1

Symbol

plch1 Nomenclature History

Previous Names

si:ch211-203b20.8

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human PLCH1 (phospholipase C eta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Jelen et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plch1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Holoprosencephaly 14	619895

Associated With plch1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR000008	C2 domain
Domain	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
Domain	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002048	EF-hand domain
Domain	IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain
Domain	IPR028392	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, catalytic domain
Domain	IPR046972	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, EF-hand motif
Family	IPR001192	Phosphoinositide phospholipase C family
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, catalytic domain	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1, EF-hand motif	C2 domain	C2 domain superfamily	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	PH-like domain superfamily	Phosphatidylinositol-specific phospholipase C, X domain	Phosphoinositide phospholipase C family	Phosphoinositide-specific phospholipase C, EF-hand-like domain	Phospholipase C, phosphatidylinositol-specific, Y domain	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Pleckstrin homology domain
UniProtKB:A0A8M9PMN2 InterPro	1753
UniProtKB:A0A8M6Z2T4 InterPro	980
UniProtKB:A0A8M9PFX4 InterPro	1765
UniProtKB:A0A8M9PPN9 InterPro	1735
UniProtKB:A0A8M9P1F6 InterPro	1795
UniProtKB:A0A8M9PVZ6 InterPro	1715
UniProtKB:A0A8M9PAI3 InterPro	1775
UniProtKB:A0A8M6YTQ9 InterPro	979

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	plch1-201 (1) Ensembl	Ensembl		9,537 nt	Select Tool ZFIN BLAST
mRNA	plch1-202 (1) Ensembl	Ensembl		3,035 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations