Gene
serpini1
- ID
- ZDB-GENE-060503-390
- Name
- serpin peptidase inhibitor, clade I (neuroserpin), member 1
- Symbol
- serpini1 Nomenclature History
- Previous Names
-
- si:ch211-167c22.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within regulation of neuron projection development; response to oxidative stress; and thigmotaxis. Predicted to be active in extracellular space. Is expressed in hypothalamus; lapillus; midbrain; otolith; and telencephalon. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial encephalopathy with neuroserpin inclusion bodies | Alliance | Encephalopathy, familial, with neuroserpin inclusion bodies | 604218 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DJI9
|
415 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpini1-201
(1)
|
Ensembl | 4,689 nt |
Interactions and Pathways
No data available
Plasmids
No data available