ripor2

ID

ZDB-GENE-060503-342

Name

RHO family interacting cell polarization regulator 2

Symbol

ripor2 Nomenclature History

Previous Names

fam65b (1)
si:dkey-218n20.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable 14-3-3 protein binding activity. Acts upstream of or within sensory perception of sound and skeletal muscle fiber development. Predicted to be located in cytoplasm; cytoskeleton; and filopodium. Is expressed in central nervous system; eye; muscle; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 21 and autosomal recessive nonsyndromic deafness 104. Orthologous to human RIPOR2 (RHO family interacting cell polarization regulator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ripor2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 21	Alliance	Deafness, autosomal dominant 21	607017
autosomal recessive nonsyndromic deafness 104	Alliance	?Deafness, autosomal recessive 104	616515

Associated With ripor2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR031780	FAM65, N-terminal
Family	IPR026136	RIPOR family member 3
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PRN0	InterPro	1033
UniProtKB:A0A8M9PND7	InterPro	999
UniProtKB:Q1LU99	InterPro	1083
UniProtKB:A0A8M3AVL4	InterPro	1022
UniProtKB:A0A8M2B6I2	InterPro	1034