ZFIN is now using GRCz12tu for Genomic Data
Gene
dot1l
- ID
- ZDB-GENE-060503-341
- Name
- DOT1 like histone lysine methyltransferase
- Symbol
- dot1l Nomenclature History
- Previous Names
-
- si:dkey-211f22.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Unknown
- Description
- Predicted to enable histone H3K79 methyltransferase activity. Acts upstream of or within canonical Wnt signaling pathway; intestinal epithelial structure maintenance; and swimming behavior. Predicted to be located in chromosome, telomeric region and cytoplasm. Predicted to be active in nucleus. Is expressed in hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in Nil-Deshwar neurodevelopmental syndrome and acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Nil-Deshwar neurodevelopmental syndrome | Alliance | Nil-Deshwar neurodevelopmental syndrome | 621265 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers