Gene
slc12a10.1
- ID
- ZDB-GENE-060503-330
- Name
- solute carrier family 12 member 10, tandem duplicate 1
- Symbol
- slc12a10.1 Nomenclature History
- Previous Names
-
- si:dkey-114c3.1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to act upstream of or within sodium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including blood; eye; heart; liver; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38591 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Amino acid permease, N-terminal | Amino acid permease/ SLC12A domain | SLC12A transporter, C-terminal | SLC12A transporter family | Thiazide-sensitive Na-K-Cl co-transporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NSZ0 | InterPro | 1033 | |||||
| UniProtKB:A0A8M9QH50 | InterPro | 1032 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc12a10.1-201
(1)
|
Ensembl | 3,102 nt | ||
| mRNA |
slc12a10.1-202
(1)
|
Ensembl | 3,063 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-83F18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-114C3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161378 (1) | 3102 nt | ||
| Genomic | GenBank:CR318646 (1) | 224271 nt | ||
| Polypeptide | UniProtKB:A0A8M1NSZ0 (1) | 1033 aa |
No data available
- Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203
- Hsu, H.H., Lin, L.Y., Tseng, Y.C., Horng, J.L., Hwang, P.P. (2014) A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Cell and tissue research. 357(1):225-43
- Wang, Y.F., Tseng, Y.C., Yan, J.J., Hiroi, J., and Hwang, P.P. (2009) Role of SLC12A10.2, a Na-Cl cotransporter-like protein, in a Cl uptake mechanism in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1650-R1660
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