Gene

sh3pxd2aa

ID

ZDB-GENE-060503-271

Name

SH3 and PX domains 2Aa

Symbol

sh3pxd2aa Nomenclature History

Previous Names

sh3pxd2a
si:dkey-82d4.2
Tks5 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have phosphatidylinositol binding activity and superoxide-generating NADPH oxidase activator activity. Involved in neural crest cell migration and posterior lateral line neuromast primordium migration. Predicted to localize to cytoplasm and podosome. Orthologous to human SH3PXD2A (SH3 and PX domains 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sh3pxd2aa Human Ortholog

No data available

Associated With sh3pxd2aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR001683	Phox homology
Domain	IPR035449	SH3PXD2A, SH3 domain 3
Domain	IPR035450	SH3PXD2A, SH3 domain 1
Domain	IPR035452	SH3PXD2A, SH3 domain 2
Domain	IPR035453	SH3PXD2A, SH3 domain 4
Domain	IPR035454	SH3PXD2A, SH3 domain 5
Domain	IPR037961	SH3PXD2, PX domain
Family	IPR001655	Neutrophil cytosol factor 1
Family	IPR051228	NADPH Oxidase and PX Domain-Containing
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036871	PX domain superfamily

Domain Details Per Protein

Protein	Length	NADPH Oxidase and PX Domain-Containing	Neutrophil cytosol factor 1	Phox homology	PX domain superfamily	SH3 domain	SH3-like domain superfamily	SH3PXD2A, SH3 domain 1	SH3PXD2A, SH3 domain 2	SH3PXD2A, SH3 domain 3	SH3PXD2A, SH3 domain 4	SH3PXD2A, SH3 domain 5	SH3PXD2, PX domain
UniProtKB:T1ECT1 InterPro	1068
UniProtKB:A0A8M3AJW2 InterPro	1135
UniProtKB:A0A8M9PV95 InterPro	1112
UniProtKB:Q1LYG0 InterPro	1119
UniProtKB:A0A8M9Q6F9 InterPro	1124
UniProtKB:A0A8M9PV85 InterPro	1140
UniProtKB:A0A8M3AKQ0 InterPro	1107