Gene
tinagl1
- ID
- ZDB-GENE-060503-240
- Name
- tubulointerstitial nephritis antigen-like 1
- Symbol
- tinagl1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type peptidase activity and peptidase inhibitor activity. Acts upstream of or within embryonic viscerocranium morphogenesis and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space and lysosome. Orthologous to several human genes including TINAGL1 (tubulointerstitial nephritis antigen like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010796Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020838Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11655 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tinagl1 | N/A | (2) |
| MO2-tinagl1 | N/A | Neiswender et al., 2017 |
| MO3-tinagl1 | N/A | Neiswender et al., 2017 |
| MO4-tinagl1 | N/A | Boopathy et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR001212 | Somatomedin B domain |
| Domain | IPR008037 | Pacifastin domain |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR036201 | Pacifastin domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine peptidase, asparagine active site | Cysteine peptidase, histidine active site | Pacifastin domain | Pacifastin domain superfamily | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal | Somatomedin B domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A3KNG7 | InterPro | 471 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tinagl1-201
(1)
|
Ensembl | 1,759 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-158B13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:161996 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044977 (1) | 1780 nt | ||
| Genomic | GenBank:BX950864 (1) | 185429 nt | ||
| Polypeptide | UniProtKB:A3KNG7 (1) | 471 aa |
- Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831
- Boopathy, G.T.K., Kulkarni, M., Ho, S.Y., Boey, A., Chua, E.W.M., Barathi, V.A., Carney, T.J., Wang, X., Hong, W. (2017) Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis. The Journal of biological chemistry. 292(43):17760-17776
- Neiswender, H., Navarre, S., Kozlowski, D.J., LeMosy, E.K. (2017) Early Craniofacial Defects in Zebrafish That Have Reduced Function of a Wnt-Interacting Extracellular Matrix Protein, Tinagl1. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 54(4):381-390
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Brown, L.J., Alawoki, M., Crawford, M.E., Reida, T., Sears, A., Torma, T., and Albig, A.R. (2010) Lipocalin-7 Is a Matricellular Regulator of Angiogenesis. PLoS One. 5(11):e13905
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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