Gene
ptprua
- ID
- ZDB-GENE-060503-232
- Name
- protein tyrosine phosphatase receptor type Ua
- Symbol
- ptprua Nomenclature History
- Previous Names
-
- si:ch211-82g18.1
- si:dkey-153p21.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in neuron projection development and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from van Eekelen et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa36806 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR000998 | MAM domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | MAM domain | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Receptor-type Tyrosine-protein Phosphatases | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A2R8QCZ8
|
1478 | |||||||||||||
UniProtKB:A0A8M3AVF9
|
1451 | |||||||||||||
UniProtKB:A0A0R4IMC4
|
1472 | |||||||||||||
UniProtKB:A0A8M3B3F6
|
1475 | |||||||||||||
UniProtKB:F1Q6E0
|
1454 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ptprua-201
(1)
|
Ensembl | 5,837 nt | ||
mRNA |
ptprua-202
(1)
|
Ensembl | 761 nt | ||
mRNA |
ptprua-203
(1)
|
Ensembl | 8,305 nt | ||
mRNA |
ptprua-204
(1)
|
Ensembl | 8,323 nt | ||
mRNA |
ptprua-205
(1)
|
Ensembl | 8,269 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-1K7 | ZFIN Curated Data | |
Contained in | BAC | CH211-82G18 | ZFIN Curated Data | |
Contained in | BAC | CH211-196L2 | ZFIN Curated Data | |
Contained in | BAC | DKEY-153P21 | ZFIN Curated Data | |
Contained in | BAC | DKEY-155F13 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_005159552 (1) | 5900 nt | ||
Genomic | GenBank:AL929594 (2) | 188746 nt | ||
Polypeptide | UniProtKB:A0A2R8QCZ8 (1) | 1478 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
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