Gene
rad21b
- ID
- ZDB-GENE-060503-223
- Name
- RAD21 cohesin complex component b
- Symbol
- rad21b Nomenclature History
- Previous Names
-
- si:ch211-246f9.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to act upstream of or within several processes, including DNA repair; apoptotic process; and chromosome segregation. Predicted to be located in chromosome, centromeric region; cytosol; and nucleus. Predicted to be part of cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cornelia de Lange syndrome 4 | Alliance | Cornelia de Lange syndrome 4 | 614701 |
| ?Mungan syndrome | 611376 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006909 | Rad21/Rec8-like protein, C-terminal, eukaryotic |
| Domain | IPR006910 | Rad21/Rec8-like protein, N-terminal |
| Domain | IPR049589 | NXP-1, middle HEAT-repeat binding domain |
| Family | IPR039781 | Rad21/Rec8-like protein |
| Homologous_superfamily | IPR023093 | ScpA-like, C-terminal |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | NXP-1, middle HEAT-repeat binding domain | Rad21/Rec8-like protein | Rad21/Rec8-like protein, C-terminal, eukaryotic | Rad21/Rec8-like protein, N-terminal | ScpA-like, C-terminal | Winged helix DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1L8E1
|
637 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rad21b-201
(1)
|
Ensembl | 2,230 nt | ||
| mRNA |
rad21b-202
(1)
|
Ensembl | 1,914 nt |
Interactions and Pathways
No data available
Plasmids
No data available