Gene

icam3

ID

ZDB-GENE-060503-219

Name

intercellular adhesion molecule 3

Symbol

icam3 Nomenclature History

Previous Names

si:ch211-233g21.1 (1)
si:ch211-74m13.3
vcap1x1 (1)
vcap1x2 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Acts upstream of or within cardiac muscle contraction and ventricular cardiac muscle cell development. Predicted to be located in membrane. Is expressed in cardiovascular system. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and uveitis (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1); ICAM3 (intercellular adhesion molecule 3); and ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Hsieh et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Hsieh et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With icam3 Human Ortholog

No data available

Associated With icam3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
dilated cardiomyopathy	icam3^as31Gt	standard conditions	Hsieh et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003987	Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013768	Intercellular adhesion molecule, N-terminal
Family	IPR047012	Intercellular adhesion molecule/vascular cell adhesion molecule
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Intercellular adhesion molecule, N-terminal	Intercellular adhesion molecule/vascular cell adhesion molecule	Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
UniProtKB:A0A8M9PGN2 InterPro	251
UniProtKB:A0A8M9Q5K3 InterPro	255
UniProtKB:A0A8M1RDF3 InterPro	551
UniProtKB:F6PCI7 InterPro	274
UniProtKB:B8JHX2 InterPro	360

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	icam3-201 (1) Ensembl	Ensembl		1,212 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-74m13.3-202 (1) Ensembl	Ensembl		1,673 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations