Gene

dock11

ID

ZDB-GENE-060503-196

Name

dedicator of cytokinesis 11

Symbol

dock11 Nomenclature History

Previous Names

si:ch211-150g2.3

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of GTPase activity and positive regulation of filopodium assembly. Predicted to act upstream of or within small GTPase mediated signal transduction. Orthologous to human DOCK11 (dedicator of cytokinesis 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dock11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Autoinflammatory disease, multisystem, with immune dysregulation, X-linked	301109

Associated With dock11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR021816	Dedicator of cytokinesis C/D, N-terminal
Domain	IPR027007	C2 DOCK-type domain
Domain	IPR027357	DOCKER domain
Domain	IPR037809	Dedicator of cytokinesis D, C2 domain
Domain	IPR046769	DOCKER, Lobe A
Domain	IPR046770	DOCKER, Lobe B
Domain	IPR046773	DOCKER, Lobe C
Family	IPR026791	Dedicator of cytokinesis
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR043161	Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily	IPR043162	Dedicator of cytokinesis, C-terminal, lobe C

Domain Details Per Protein

Protein	Length	C2 DOCK-type domain	C2 domain superfamily	Dedicator of cytokinesis	Dedicator of cytokinesis C/D, N-terminal	Dedicator of cytokinesis, C-terminal, lobe A	Dedicator of cytokinesis, C-terminal, lobe C	Dedicator of cytokinesis D, C2 domain	DOCKER domain	DOCKER, Lobe A	DOCKER, Lobe B	DOCKER, Lobe C	PH-like domain superfamily	Pleckstrin homology domain
UniProtKB:A0A8M9Q1V0 InterPro	2041
UniProtKB:B0R034 InterPro	2067
UniProtKB:A0A0R4ILW7 InterPro	2057
UniProtKB:A0A8M9PP60 InterPro	2054

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dock11-201 (1) Ensembl	Ensembl	6,209 nt	Select Tool ZFIN BLAST
mRNA	dock11-202 (1) Ensembl	Ensembl	9,964 nt	Select Tool ZFIN BLAST
mRNA	dock11-203 (1) Ensembl	Ensembl	9,806 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations