Gene
adarb2
- ID
- ZDB-GENE-060503-160
- Name
- adenosine deaminase RNA specific B2 (inactive)
- Symbol
- adarb2 Nomenclature History
- Previous Names
-
- si:dkey-255g15.1
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to localize to cytoplasm and nucleolus. Is expressed in brain and spinal cord. Orthologous to human ADARB2 (adenosine deaminase RNA specific B2 (inactive)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | ADAR3, first double-stranded RNA binding domain | Adenosine deaminase/editase | Double-stranded RNA-binding domain |
---|---|---|---|---|
UniProtKB:A0A8M3AVV9
|
714 | |||
UniProtKB:A0A8N7T6M9
|
740 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
adarb2-201
(1)
|
Ensembl | 2,458 nt | ||
mRNA |
adarb2-202
(1)
|
Ensembl | 2,731 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-81I19 | ZFIN Curated Data | |
Contained in | BAC | CH211-113J3 | ZFIN Curated Data | |
Contained in | BAC | DKEY-255G15 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068217137 (1) | 12246 nt | ||
Genomic | GenBank:CR925792 (1) | 183618 nt | ||
Polypeptide | UniProtKB:A0A8N7T6M9 (1) | 740 aa |
- Niescierowicz, K., Pryszcz, L., Navarrete, C., Tralle, E., Sulej, A., Abu Nahia, K., Kasprzyk, M.E., Misztal, K., Pateria, A., Pakuła, A., Bochtler, M., Winata, C. (2022) Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish. Nature communications. 13:5520
- Xie, Y., Kaufmann, D., Moulton, M.J., Panahi, S., Gaynes, J.A., Watters, H.N., Zhou, D., Xue, H.H., Fung, C.M., Levine, E.M., Letsou, A., Brennan, K.C., Dorsky, R.I. (2017) Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biology. 15:e2002257
- Shamay-Ramot, A., Khermesh, K., Porath, H.T., Barak, M., Pinto, Y., Wachtel, C., Zilberberg, A., Lerer-Goldshtein, T., Efroni, S., Levanon, E.Y., Appelbaum, L. (2015) Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish. PLoS Genetics. 11:e1005702
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