Gene

arsg

ID

ZDB-GENE-060503-154

Name

arylsulfatase G

Symbol

arsg Nomenclature History

Previous Names

si:dkey-220f10.7

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable arylsulfatase activity. Human ortholog(s) of this gene implicated in Usher syndrome. Orthologous to human ARSG (arylsulfatase G).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa35276	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With arsg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Usher syndrome, type IV	618144

Associated With arsg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR024607	Sulfatase, conserved site
Domain	IPR000917	Sulfatase, N-terminal
Family	IPR050738	Sulfatase enzyme
Homologous_superfamily	IPR017850	Alkaline-phosphatase-like, core domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Alkaline-phosphatase-like, core domain superfamily	Sulfatase, conserved site	Sulfatase enzyme	Sulfatase, N-terminal
UniProtKB:A4QP89	InterPro	526

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 12

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	arsg-201 (1) Ensembl	Ensembl		2,310 nt	Select Tool ZFIN BLAST
mRNA	arsg-202 (1) Ensembl	Ensembl		533 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-106L8	FP885542	ZFIN Curated Data
Contained in	BAC	DKEY-220F10	CR926135	ZFIN Curated Data
Encodes	cDNA	MGC:163043	BC139702	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_068217914 (1)	2156 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	RefSeq:NW_008805585 (1)	42677 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A4QP89 (1)	526 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	ARSG	17	Ensembl:ENSG00000141337 Gene:22901 HGNC:24102 OMIM:610008	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Arsg	11	Ensembl:ENSMUSG00000020604 Gene:74008 MGI:1921258	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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