Gene
lpin2
- ID
- ZDB-GENE-060503-153
- Name
- lipin 2
- Symbol
- lpin2 Nomenclature History
- Previous Names
-
- lipin2 (1)
- si:dkey-216e9.8
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in cytosol; endoplasmic reticulum membrane; and nucleus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN2 (lipin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Majeed syndrome | 609628 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | HAD-like superfamily | HAD superfamily | LIPIN family | Lipin, middle domain | Lipin/Ned1/Smp2 (LNS2) | Lipin, N-terminal | LNS2/PITP |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAN1 | InterPro | 941 | |||||||
| UniProtKB:F1RAK9 | InterPro | 904 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-216E9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005163454 (1) | 4996 nt | ||
| Genomic | GenBank:AL929096 (1) | 192592 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAN1 (1) | 941 aa |
- Chen, B., Zheng, Y.M., Zhang, J.P. (2018) Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. Frontiers in endocrinology. 9:366
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sapp, V., Gaffney, L., EauClaire, S.F., Matthews, R.P. (2014) Fructose leads to hepatic steatosis in zebrafish that is reversed by mTOR inhibition. Hepatology (Baltimore, Md.). 60(5):1581-92
- Sundström, G., Dreborg, S., and Larhammar, D. (2010) Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One. 5(5):e10512
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