Gene
magixa
- ID
- ZDB-GENE-060503-115
- Name
- MAGI family member, X-linked a
- Symbol
- magixa Nomenclature History
- Previous Names
-
- si:ch211-157c18.2
- si:ch211-202d20.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGIX (MAGI family member, X-linked).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016302Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2451 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21277 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34384 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41190 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-magixa | (2) | |
| CRISPR2-magixa | (2) | |
| CRISPR3-magixa | (2) | |
| CRISPR4-magixa | (2) | |
| CRISPR5-magixa | (2) | |
| CRISPR6-magixa | (2) | |
| CRISPR7-magixa | (2) | |
| CRISPR8-magixa | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001202 | WW domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P9V0 | InterPro | 1309 | ||||||||
| UniProtKB:A0A8M9QE50 | InterPro | 1076 | ||||||||
| UniProtKB:A0A8M9QIX5 | InterPro | 1309 | ||||||||
| UniProtKB:A0A8M9PL44 | InterPro | 1076 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
magixa-202
(1)
|
Ensembl | 3,118 nt | ||
| mRNA |
magixa-203
(1)
|
Ensembl | 4,082 nt | ||
| mRNA |
magixa-204
(1)
|
Ensembl | 4,781 nt | ||
| mRNA |
magixa-205
(1)
|
Ensembl | 4,130 nt | ||
| ncRNA |
magixa-002
(1)
|
Ensembl | 745 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157C18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-202D20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001337212 (1) | |||
| Genomic | RefSeq:NW_018395272 (1) | |||
| Polypeptide | UniProtKB:A0A8M9P9V0 (1) | 1309 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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