Gene
kiaa0319l
- ID
- ZDB-GENE-060503-110
- Name
- KIAA0319-like
- Symbol
- kiaa0319l Nomenclature History
- Previous Names
-
- si:ch211-193k19.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be involved in neuron migration. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and membrane. Is expressed in axis; brain; head; otic vesicle; and trunk. Orthologous to human KIAA0319L (KIAA0319 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Gostic et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3023 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9917 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13528 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19220 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36911 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43340 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dyslexia-associated protein KIAA0319-like | Immunoglobulin-like fold | PKD/Chitinase domain | PKD domain | PKD domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RTA0 | InterPro | 949 | |||||
| UniProtKB:A0A8M2B6J5 | InterPro | 951 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-193k19.1-201
(1)
|
Ensembl | 2,517 nt | ||
| mRNA |
si:ch211-193k19.1-202
(1)
|
Ensembl | 3,905 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-193K19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068215332 (1) | 4467 nt | ||
| Genomic | GenBank:CR356238 (1) | 91311 nt | ||
| Polypeptide | UniProtKB:A0A8M2B6J5 (1) | 951 aa |
- Gostic, M., Martinelli, A., Tucker, C., Yang, Z., Gasparoli, F., Ewart, J.Y., Dholakia, K., Sillar, K.T., Tello, J.A., Paracchini, S. (2019) The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration. The Journal of comparative neurology. 527(16):2634-2643
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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