Gene

f9b

ID

ZDB-GENE-060421-7346

Name

coagulation factor IXb

Symbol

f9b Nomenclature History

Previous Names

zgc:136807

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation and proteolysis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in hemophilia B and thrombophilia. Orthologous to human F9 (coagulation factor IX).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Iyer et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With f9b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hemophilia B	Alliance	Hemophilia B	306900
X-linked thrombophilia due to factor IX defect	Alliance	Thrombophilia 8, X-linked, due to factor IX defect	300807
X-linked thrombophilia due to factor IX defect	Alliance	{Deep venous thrombosis, protection against}	300807
X-linked warfarin sensitivity	Alliance	{Warfarin sensitivity}	301052

Associated With f9b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018114	Serine proteases, trypsin family, histidine active site
Active_site	IPR033116	Serine proteases, trypsin family, serine active site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
Domain	IPR000742	EGF-like domain
Domain	IPR001254	Serine proteases, trypsin domain
Domain	IPR001881	EGF-like calcium-binding domain
Family	IPR001314	Peptidase S1A, chymotrypsin family
Family	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
Family	IPR050442	Peptidase S1 family, coagulation factors
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR017857	Coagulation factor-like, Gla domain superfamily
Homologous_superfamily	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site