Gene

emg1

ID

ZDB-GENE-060421-2909

Name

EMG1 N1-specific pseudouridine methyltransferase

Symbol

emg1 Nomenclature History

Previous Names

zgc:136360 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable rRNA (pseudouridine) methyltransferase activity and rRNA binding activity. Predicted to be involved in rRNA base methylation. Predicted to act upstream of or within ribosome biogenesis. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Orthologous to human EMG1 (EMG1 N1-specific pseudouridine methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With emg1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bowen-Conradi syndrome	Alliance	Bowen-Conradi syndrome	211180

Associated With emg1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005304	Ribosomal biogenesis, methyltransferase, EMG1/NEP1
Homologous_superfamily	IPR029026	tRNA (guanine-N1-)-methyltransferase, N-terminal
Homologous_superfamily	IPR029028	Alpha/beta knot methyltransferases