Gene
sec31b
- ID
- ZDB-GENE-060418-2
- Name
- SEC31 homolog B, COPII coat complex component
- Symbol
- sec31b Nomenclature History
- Previous Names
-
- sec31l2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in COPII-coated vesicle cargo loading and endoplasmic reticulum organization. Predicted to act upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SEC31B (SEC31 homolog B, COPII coat complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Niu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Niu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018320Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa873 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10739 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42098 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42099 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-sec31b | N/A | Niu et al., 2014 |
| MO2-sec31b | N/A | Niu et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR024298 | Sec16, Sec23-binding domain |
| Family | IPR040251 | Protein transport protein SEC31-like |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein transport protein SEC31-like | Sec16, Sec23-binding domain | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F114 | InterPro | 1171 | ||||||
| UniProtKB:A0A8M2BKB4 | InterPro | 1174 | ||||||
| UniProtKB:A0AB32U4U0 | InterPro | 1184 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sec31b-201
(1)
|
Ensembl | 4,073 nt | ||
| mRNA |
sec31b-202
(1)
|
Ensembl | 422 nt | ||
| mRNA |
sec31b-204
(1)
|
Ensembl | 4,172 nt | ||
| ncRNA |
sec31b-003
(1)
|
Ensembl | 758 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-183O18 | ZFIN Curated Data | |
| Contained in | BAC | CH73-300E14 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-448P6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068224841 (1) | 5667 nt | ||
| Genomic | GenBank:FP102054 (2) | 96657 nt | ||
| Polypeptide | UniProtKB:A0AB32U4U0 (1) | 1184 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Niu, X., Hong, J., Zheng, X., Melville, D.B., Knapik, E.W., Meng, A., Peng, J. (2014) The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development. The Journal of biological chemistry. 289:11971-85
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Niu, X., Gao, C., Jan Lo, L., Luo, Y., Meng, C., Hong, J., Hong, W., and Peng, J. (2012) Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish. Developmental Biology. 367(2):197-207
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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