Gene
slc6a4b
- ID
- ZDB-GENE-060314-2
- Name
- solute carrier family 6 member 4b
- Symbol
- slc6a4b Nomenclature History
- Previous Names
-
- sertb (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have serotonin binding activity and serotonin:sodium symporter activity. Predicted to be involved in serotonin uptake. Predicted to localize to neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anxiety disorder (multiple); autistic disorder; heart disease (multiple); and obstructive sleep apnea. Is expressed in nervous system. Orthologous to human SLC6A4 (solute carrier family 6 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anxiety disorder | Alliance | {Anxiety-related personality traits} | 607834 |
| {Obsessive-compulsive disorder} | 164230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|
|
UniProtKB:B3DJ31
|
591 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a4b-201
(1)
|
Ensembl | 1,852 nt |
Interactions and Pathways
No data available
Plasmids
No data available