Gene
slc6a4a
- ID
- ZDB-GENE-060314-1
- Name
- solute carrier family 6 member 4a
- Symbol
- slc6a4a Nomenclature History
- Previous Names
-
- serta (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Exhibits drug binding activity and serotonin:sodium symporter activity. Involved in serotonin transport. Predicted to localize to neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anxiety disorder (multiple); autistic disorder; heart disease (multiple); and obstructive sleep apnea. Is expressed in brain; pharynx; and spinal cord. Orthologous to human SLC6A4 (solute carrier family 6 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anxiety disorder | Alliance | {Anxiety-related personality traits} | 607834 |
| {Obsessive-compulsive disorder} | 164230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|
|
UniProtKB:A0A8M3APU9
|
420 | ||
|
UniProtKB:Q1WGB5
|
646 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a4a-201
(1)
|
Ensembl | 2,166 nt | ||
| ncRNA |
slc6a4a-002
(1)
|
Ensembl | 540 nt | ||
| ncRNA |
slc6a4a-003
(1)
|
Ensembl | 539 nt |
Interactions and Pathways
No data available
Plasmids
No data available