Gene
tamalin
- ID
- ZDB-GENE-060312-30
- Name
- trafficking regulator and scaffold protein tamalin
- Symbol
- tamalin Nomenclature History
- Previous Names
-
- grasp
- graspl
- tamalin (1)
- zgc:136876
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Acts upstream of or within regulation of neuron apoptotic process; regulation of oligodendrocyte apoptotic process; and spinal cord development. Predicted to be located in cytoplasm. Is expressed in spinal cord. Orthologous to human TAMALIN (trafficking regulator and scaffold protein tamalin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Seo et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tamalin | Seo et al., 2022 | |
| MO1-tamalin | N/A | Seo et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intracellular Trafficking and Signaling Regulator | PDZ domain | PDZ superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q29RA7 | InterPro | 382 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-286N19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136876 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039924 (1) | 2334 nt | ||
| Genomic | GenBank:AL807377 (1) | 170231 nt | ||
| Polypeptide | UniProtKB:Q29RA7 (1) | 382 aa |
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Seo, Y., Mo, S., Kim, S., Kim, H., Park, H.C. (2022) Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. International Journal of Molecular Sciences. 23(21):
- Pikulkaew, S., Benato, F., Celeghin, A., Zucal, C., Skobo, T., Colombo, L., and Dalla Valle , L. (2011) The knockdown of maternal glucocorticoid receptor mRNA alters embryo development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(4):874-889
- Riley, B.B., Sweet, E.M., Heck, R., Evans, A., McFarland, K.N., Warga, R.M., and Kane, D.A. (2010) Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(3):828-843
- Kitano, J., Yamazaki, Y., Kimura, K., Masukado, T., Nakajima, Y., and Nakanishi, S. (2003) Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. The Journal of biological chemistry. 278(17):14762-14768
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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