Gene
zgc:136908
- ID
- ZDB-GENE-060312-22
- Name
- zgc:136908
- Symbol
- zgc:136908 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ERAD pathway; autophagosome maturation; and mitotic spindle disassembly. Predicted to localize to VCP-NPL4-UFD1 AAA ATPase complex; cytosol; and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003338 | CDC48, N-terminal subdomain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR004201 | CDC48, domain 2 |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR005938 | AAA ATPase, CDC48 family |
| Family | IPR050168 | AAA ATPase domain-containing protein |
| Homologous_superfamily | IPR009010 | Aspartate decarboxylase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029067 | CDC48 domain 2-like superfamily |
Domain Details Per Protein
| Protein | Length | AAA ATPase, AAA+ lid domain | AAA ATPase, CDC48 family | AAA+ ATPase domain | AAA ATPase domain-containing protein | Aspartate decarboxylase-like domain superfamily | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | CDC48, domain 2 | CDC48 domain 2-like superfamily | CDC48, N-terminal subdomain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q29RA2
|
805 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zgc:136908-201
(1)
|
Ensembl | 2,864 nt |
Interactions and Pathways
No data available
Plasmids
No data available