Gene
kcnj11
- ID
- ZDB-GENE-060308-2
- Name
- potassium inwardly rectifying channel subfamily J member 11
- Symbol
- kcnj11 Nomenclature History
- Previous Names
-
- Kir6.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have ATP-activated inward rectifier potassium channel activity. Involved in type B pancreatic cell development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
familial hyperinsulinemic hypoglycemia 2 | Alliance | Hyperinsulinemic hypoglycemia, familial, 2 | 601820 |
maturity-onset diabetes of the young type 13 | Alliance | Maturity-onset diabetes of the young, type 13 | 616329 |
transient neonatal diabetes mellitus | Alliance | Diabetes mellitus, transient neonatal 3 | 610582 |
type 2 diabetes mellitus | Alliance | {Diabetes mellitus, type 2, susceptibility to} | 125853 |
Diabetes, permanent neonatal 2, with or without neurologic features | 618856 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
Family | IPR003279 | Potassium channel, inwardly rectifying, Kir6.2 |
Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Domain Details Per Protein
Protein | Length | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir6.2 | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
---|---|---|---|---|---|---|---|
UniProtKB:Q2HX26
|
381 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
kcnj11-201
(1)
|
Havana | 1146 nt |
Interactions and Pathways
No data available
Plasmids