Gene

kcnj11

ID
ZDB-GENE-060308-2
Name
potassium inwardly rectifying channel subfamily J member 11
Symbol
kcnj11 Nomenclature History
Previous Names
  • Kir6.2 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have ATP-activated inward rectifier potassium channel activity. Involved in type B pancreatic cell development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnj11 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hyperinsulinemic hypoglycemia 2 Alliance Hyperinsulinemic hypoglycemia, familial, 2 601820
maturity-onset diabetes of the young type 13 Alliance Maturity-onset diabetes of the young, type 13 616329
transient neonatal diabetes mellitus Alliance Diabetes mellitus, transient neonatal 3 610582
type 2 diabetes mellitus Alliance {Diabetes mellitus, type 2, susceptibility to} 125853
Diabetes, permanent neonatal 2, with or without neurologic features 618856
Associated With kcnj11 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
Domain IPR041647 Inward rectifier potassium channel, C-terminal
Family IPR003279 Potassium channel, inwardly rectifying, Kir6.2
Family IPR016449 Potassium channel, inwardly rectifying, Kir
Homologous_superfamily IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Homologous_superfamily IPR014756 Immunoglobulin E-set
Domain Details Per Protein
Protein Length Immunoglobulin E-set Inward rectifier potassium channel, C-terminal Potassium channel, inwardly rectifying, Kir Potassium channel, inwardly rectifying, Kir6.2 Potassium channel, inwardly rectifying, Kir, cytoplasmic Potassium channel, inwardly rectifying, transmembrane domain
UniProtKB:Q2HX26 381
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA kcnj11-201 (1) Havana 1146 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations