Gene

cubn

ID
ZDB-GENE-060228-6
Name
cubilin (intrinsic factor-cobalamin receptor)
Symbol
cubn Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Is expressed in pronephric duct; pronephric tubule; proximal convoluted tubule; and proximal straight tubule. Orthologous to human CUBN (cubilin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Park et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cubn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
megaloblastic anemia Alliance Imerslund-Grasbeck syndrome 1 261100
[Proteinuria, chronic benign] 618884
Associated With cubn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR024731 EGF domain
Family IPR028876 Cubilin
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length CUB domain Cubilin EGF domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Spermadhesin, CUB domain superfamily
UniProtKB:B0JZN9 459
UniProtKB:A0A0R4IIW6 3626
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations