Gene

cubn

ID

ZDB-GENE-060228-6

Name

cubilin (intrinsic factor-cobalamin receptor)

Symbol

cubn Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Is expressed in pronephric duct; pronephric tubule; proximal convoluted tubule; and proximal straight tubule. Orthologous to human CUBN (cubilin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Park et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cubn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
megaloblastic anemia	Alliance	Imerslund-Grasbeck syndrome 1	261100
		[Proteinuria, chronic benign]	618884

Associated With cubn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000859	CUB domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR024731	EGF domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	CUB domain	EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	NOTCH1 EGF-like calcium-binding domain	Spermadhesin, CUB domain superfamily
UniProtKB:A0A8M9PME6 InterPro	3626

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cubn-201 (1) Ensembl	Ensembl		10,878 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations