ZFIN is now using GRCz12tu for Genomic Data
Gene
cnksr2a
- ID
- ZDB-GENE-060228-5
- Name
- connector enhancer of kinase suppressor of Ras 2a
- Symbol
- cnksr2a Nomenclature History
- Previous Names
-
- cnksr2
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in enzyme-linked receptor protein signaling pathway and postsynaptic specialization organization. Predicted to act upstream of or within phosphorylation and regulation of signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked mental retardation Hough type | Alliance | Intellectual developmental disorder, X-linked syndromic, Houge type | 301008 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR010599 | Connector enhancer of kinase suppressor of ras 2/3 domain |
| Domain | IPR017874 | CRIC domain |
| Domain | IPR049628 | CNK1-3, SAM domain |
| Family | IPR051566 | Connector enhancer of kinase suppressor of Ras |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnksr2a-201
(1)
|
Ensembl | 3,057 nt | ||
| mRNA |
cnksr2a-202
(1)
|
Ensembl | 2,050 nt | ||
| mRNA |
cnksr2a-203
(1)
|
Ensembl | 2,685 nt | ||
| mRNA |
cnksr2a-204
(1)
|
Ensembl | 1,959 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers