Gene
lgi2b
- ID
- ZDB-GENE-060217-3
- Name
- leucine-rich repeat LGI family, member 2b
- Symbol
- lgi2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. Is expressed in trigeminal ganglion. Orthologous to human LGI2 (leucine rich repeat LGI family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Family | IPR051295 | Leucine-rich glioma-inactivated/LGI-related |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | EAR | Leucine-rich glioma-inactivated , EPTP repeat | Leucine-rich glioma-inactivated/LGI-related | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q2HPF8 | InterPro | 545 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-117M1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039642 (1) | 1679 nt | ||
| Genomic | GenBank:CT737206 (1) | 96443 nt | ||
| Polypeptide | UniProtKB:Q2HPF8 (1) | 545 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
- Kegel, L., Jaegle, M., Driegen, S., Aunin, E., Leslie, K., Fukata, Y., Watanabe, M., Fukata, M., Meijer, D. (2014) Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development (Cambridge, England). 141:1749-56
- Parmar, M.B., and Wright, J.M. (2013) Comparative evolutionary genomics of medaka and three-spined stickleback fabp2a and fabp2b genes with fabp2 of zebrafish. Genome. 56(1):27-37
- Teng, Y., Xie, X., Walker, S., Saxena, M., Kozlowski, D.J., Mumm, J.S., and Cowell, J.K. (2011) Loss of Zebrafish lgi1b Leads to Hydrocephalus and Sensitization to Pentylenetetrazol Induced Seizure-Like Behavior. PLoS One. 6(9):e24596
- Gu, W., Gibert, Y., Wirth, T., Elischer, A., Bloch, W., Meyer, A., Steinlein, O.K., and Begemann, G. (2005) Using Gene-History and Expression Analyses to Assess the Involvement of LGI Genes in Human Disorders. Mol. Biol. Evol.. 22(11):2209-2216
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