Gene
ndp
- ID
- ZDB-GENE-060216-2
- Name
- norrin cystine knot growth factor NDP
- Symbol
- ndp Nomenclature History
- Previous Names
-
- si:ch211-222m21.5
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within retina vasculature development in camera-type eye. Predicted to be located in extracellular space. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in Norrie disease; X-linked exudative vitreoretinopathy 2; and retinopathy of prematurity. Orthologous to human NDP (norrin cystine knot growth factor NDP).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wu et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Norrie disease | Alliance | Norrie disease | 310600 |
| X-linked exudative vitreoretinopathy 2 | Alliance | Exudative vitreoretinopathy 2, X-linked | 305390 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine knot, C-terminal | Cystine-knot cytokine | DAN | Norrie disease protein |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QKA4
|
138 |
Interactions and Pathways
No data available
Plasmids
No data available