ZFIN ID: ZDB-GENE-060215-1
Gene Name: agouti signaling protein 1
Gene Symbol: asip1    Nomenclature History

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Previous Names: asip, zgc:194136 (1), zgc:194144 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have melanocortin receptor binding activity and neuropeptide hormone activity. Involved in pigmentation. Predicted to localize to extracellular space. Is expressed in several structures, including fat cell; integument; liver; opercle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human ASIP (agouti signaling protein).
Genome Resources: Alliance (1),  Gene:798574 (1),  Ensembl(GRCz11):ENSDARG00000077858 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
iim02 Small Deletion Unknown Unknown CRISPR
iim08 Indel Unknown Unknown CRISPR
iim016 Small Deletion Unknown Unknown CRISPR
sa13992 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18595 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-asip1 1
    MO1-asip1 N/A 2
    DISEASE ASSOCIATED WITH asip1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    [Skin/hair/eye pigmentation 9, brown/nonbrown eyes] 611742
    [Skin/hair/eye pigmentation 9, dark/light hair] 611742
    DISEASE ASSOCIATED WITH asip1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pigmentation (more)
    Cellular Component extracellular region (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA asip1-201 (1)    Ensembl 728
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM asip1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(asip1:EGFP) asip1 EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    asip1 Contained in: [BAC] DKEY-16N21 (1) (order this)
    asip1 Encodes: [cDNA] MGC:194136 (1), MGC:194144 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128801 (1) 473 nt
    Genomic GenBank:BX629346 (1) 214213 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DGI7 (1) 125 aa
    Sequence Information (all 17)
    ORTHOLOGY for asip1 ( Chr: 6 )
    CITATIONS (27)