Gene
cd8a
- ID
- ZDB-GENE-060210-2
- Name
- CD8a molecule
- Symbol
- cd8a Nomenclature History
- Previous Names
-
- zgc:136643
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to localize to integral component of membrane. Is expressed in leukocyte; lymphocyte; and spleen. Orthologous to human CD8A (CD8a molecule).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 17 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Immunodeficiency 116 | 608957 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | CD8 alpha subunit | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain |
---|---|---|---|---|---|
UniProtKB:Q24JW8
|
216 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-184P9 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136643 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193791 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001040049 (1) | 1325 nt | ||
Genomic | GenBank:BX005379 (1) | 185814 nt | ||
Polypeptide | UniProtKB:Q24JW8 (1) | 216 aa |
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Awasthi, N., Ward, A.C., Liongue, C. (2023) Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth. Frontiers in bioscience (Landmark edition). 28:187187
- Cardoso, B.A., Duque, M., Gírio, A., Fragoso, R., Oliveira, M.L., Allen, J.R., Martins, L.R., Correia, N.C., Silveira, A.B., Veloso, A., Kimura, S., Demoen, L., Matthijssens, F., Jeha, S., Cheng, C., Pui, C.H., Grosso, A.R., Neto, J.L., De Almeida, S.F., Van Vlieberghe, P., Mullighan, C.G., Yunes, J.A., Langenau, D.M., Pflumio, F., Barata, J.T. (2023) CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia. Haematologica. 109(6):1713-1725
- Heidary, S., Awasthi, N., Page, N., Allnutt, T., Lewis, R.S., Liongue, C., Ward, A.C. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and molecular life sciences : CMLS. 80:109109
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- Basheer, F., Bulleeraz, V., Ngo, V.Q.T., Liongue, C., Ward, A.C. (2022) In vivo impact of JAK3 A573V mutation revealed using zebrafish. Cellular and molecular life sciences : CMLS. 79:322
- Basheer, F., Lee, E., Liongue, C., Ward, A.C. (2022) Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation. Biomolecules. 12(10):
- Oliveira, M.L., Veloso, A., Garcia, E.G., Iyer, S., Pereira, C., Barreto, V.M., Langenau, D.M., Barata, J.T. (2022) Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia. Leukemia. 36(6):1533-1540
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