Gene
sparcl1
- ID
- ZDB-GENE-060130-6
- Name
- SPARC-like 1
- Symbol
- sparcl1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in regulation of synapse organization and semicircular canal morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in lens; lens epithelium; and lens fiber cell. Orthologous to human SPARCL1 (SPARC like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1976 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Conserved_site | IPR001999 | Osteonectin-like, conserved site |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR015369 | Follistatin/Osteonectin EGF domain |
| Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Osteonectin-like, conserved site | SPARC/Testican, calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DJ32 | InterPro | 606 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sparcl1-201
(1)
|
Ensembl | 2,310 nt | ||
| mRNA |
sparcl1-202
(1)
|
Ensembl | 801 nt | ||
| mRNA |
sparcl1-204
(1)
|
Ensembl | 4,166 nt | ||
| ncRNA |
sparcl1-003
(1)
|
Ensembl | 752 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-153L18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194744 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130605 (1) | 1922 nt | ||
| Genomic | GenBank:FP102961 (1) | 117019 nt | ||
| Polypeptide | UniProtKB:B3DJ32 (1) | 606 aa |
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Xie, Y., Xie, J., Meijer, A.H., Schaaf, M.J.M. (2021) Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages. Frontiers in immunology. 12:618569
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Lin, Q., Fan, S., Zhang, Y., Xu, M., Zhang, H., Yang, Y., Lee, A.P., Woltering, J.M., Ravi, V., Gunter, H.M., Luo, W., Gao, Z., Lim, Z.W., Qin, G., Schneider, R.F., Wang, X., Xiong, P., Li, G., Wang, K., Min, J., Zhang, C., Qiu, Y., Bai, J., He, W., Bian, C., Zhang, X., Shan, D., Qu, H., Sun, Y., Gao, Q., Huang, L., Shi, Q., Meyer, A., Venkatesh, B. (2016) The seahorse genome and the evolution of its specialized morphology. Nature. 540:395-399
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Torres-Núñez, E., Suarez-Bregua, P., Cal, L., Cal, R., Cerdá-Reverter, J.M., Rotllant, J. (2015) Molecular cloning and characterization of the matricellular protein Sparc/Osteonectin in flatfish, Scophthalmus maximus, and its developmental stage-dependent transcriptional regulation during metamorphosis. Gene. 568(2):129-39
- Kawasaki, K. (2009) The SCPP gene repertoire in bony vertebrates and graded differences in mineralized tissues. Development genes and evolution. 219(3):147-157
- Renn, J., Schaedel, M., Volff, J.N., Goerlich, R., Schartl, M., and Winkler, C. (2006) Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene. 372:208-218
- Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100
- Kawasaki, K., Suzuki, T., and Weiss, K.M. (2004) Genetic basis for the evolution of vertebrate mineralized tissue. Proceedings of the National Academy of Sciences of the United States of America. 101(31):11356-11361
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