Gene

zfpm2b

ID

ZDB-GENE-060130-5

Name

zinc finger protein, FOG family member 2b

Symbol

zfpm2b Nomenclature History

Previous Names

fog2b (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and metal ion binding activity. Predicted to be involved in cell differentiation; heart development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in anterior lateral plate mesoderm; central nervous system; midbrain; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zfpm2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
46,XY sex reversal 9	Alliance	46XY sex reversal 9	616067
congenital diaphragmatic hernia	Alliance	Diaphragmatic hernia 3	610187
tetralogy of Fallot	Alliance	Tetralogy of Fallot	187500

Associated With zfpm2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR034731	Zinc finger CCHC FOG-type
Domain	IPR049361	Zinc finger protein ZFPM1/2, PR domain
Family	IPR039746	FOG family
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily