Gene

zfpm2a

ID

ZDB-GENE-060130-4

Name

zinc finger protein, FOG family member 2a

Symbol

zfpm2a Nomenclature History

Previous Names

fog2a (1)
zgc:152696

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have RNA polymerase II transcription factor binding activity. Predicted to be involved in cell differentiation; heart development; and negative regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; myelodysplastic syndrome; and tetralogy of Fallot. Is expressed in midbrain. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Walton et al., 2006

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zfpm2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
46,XY sex reversal 9	Alliance	46XY sex reversal 9	616067
congenital diaphragmatic hernia	Alliance	Diaphragmatic hernia 3	610187
tetralogy of Fallot	Alliance	Tetralogy of Fallot	187500

Associated With zfpm2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR034731	Zinc finger CCHC FOG-type
Domain	IPR049361	Zinc finger protein ZFPM1/2, PR domain
Family	IPR039746	FOG family
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	FOG family	SET domain superfamily	Zinc finger C2H2 superfamily	Zinc finger C2H2-type	Zinc finger CCHC FOG-type	Zinc finger protein ZFPM1/2, PR domain
UniProtKB:Q2QKJ9 InterPro	1141
UniProtKB:F1R4T3 InterPro	1142

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zfpm2a-201 (1) Ensembl	Ensembl	4,564 nt	Select Tool ZFIN BLAST
mRNA	zfpm2a-202 (1) Ensembl	Ensembl	1,126 nt	Select Tool ZFIN BLAST
mRNA	zfpm2a-203 (1) Ensembl	Ensembl	4,142 nt	Select Tool ZFIN BLAST
mRNA	zfpm2a-204 (1) Ensembl	Ensembl	402 nt	Select Tool ZFIN BLAST
mRNA	zfpm2a-205 (1) Ensembl	Ensembl	4,007 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations