Gene
zfpm2a
- ID
- ZDB-GENE-060130-4
- Name
- zinc finger protein, FOG family member 2a
- Symbol
- zfpm2a Nomenclature History
- Previous Names
-
- fog2a (1)
- zgc:152696
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and metal ion binding activity. Predicted to be involved in cell differentiation; heart development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in midbrain. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Walton et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012971Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019806Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0270Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| nju205Gt | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa36240 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42806 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-zfpm2a | N/A | Walton et al., 2006 |
| MO2-zfpm2a | N/A | Walton et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XY sex reversal 9 | Alliance | 46XY sex reversal 9 | 616067 |
| congenital diaphragmatic hernia | Alliance | Diaphragmatic hernia 3 | 610187 |
| tetralogy of Fallot | Alliance | Tetralogy of Fallot | 187500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013087 | Zinc finger C2H2-type |
| Domain | IPR034731 | Zinc finger CCHC FOG-type |
| Domain | IPR049361 | Zinc finger protein ZFPM1/2, PR domain |
| Family | IPR039746 | FOG family |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | FOG family | SET domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger CCHC FOG-type | Zinc finger protein ZFPM1/2, PR domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q2QKJ9 | InterPro | 1141 | ||||||
| UniProtKB:F1R4T3 | InterPro | 1142 | ||||||
| UniProtKB:A0AB32TB88 | InterPro | 1089 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zfpm2a-201
(1)
|
Ensembl | 4,564 nt | ||
| mRNA |
zfpm2a-202
(1)
|
Ensembl | 1,126 nt | ||
| mRNA |
zfpm2a-203
(1)
|
Ensembl | 4,142 nt | ||
| mRNA |
zfpm2a-204
(1)
|
Ensembl | 402 nt | ||
| mRNA |
zfpm2a-205
(1)
|
Ensembl | 4,007 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-64E13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-122A22 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-55H21 | ||
| Encodes | cDNA | MGC:152696 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194070 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039635 (1) | 4007 nt | ||
| Genomic | GenBank:CR392033 (2) | 170291 nt | ||
| Polypeptide | UniProtKB:F1R4T3 (1) | 1142 aa |
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150
- Falisse, E., Ducos, B., Stockwell, P.A., Morison, I.M., Chatterjee, A., Silvestre, F. (2018) DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Environmental pollution (Barking, Essex : 1987). 243:1867-1877
- Qian, Y., Xiao, D., Guo, X., Chen, H., Hao, L., Ma, X., Huang, G., Ma, D., Wang, H. (2017) Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation. Journal of translational medicine. 15:69
- Ding, Y., Long, P.A., Bos, J.M., Shih, Y.H., Ma, X., Sundsbak, R.S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M.J., Lin, X., Ekker, S.C., Redfield, M.M., Olson, T.M., Xu, X. (2016) A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.. JCI insight. 1(14)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Walton, R.Z., Bruce, A.E., Olivey, H.E., Najib, K., Johnson, V., Earley, J.U., Ho, R.K., and Svensson, E.C. (2006) Fog1 is required for cardiac looping in zebrafish. Developmental Biology. 289(2):482-493
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