Gene
kctd8
- ID
- ZDB-GENE-060117-3
- Name
- potassium channel tetramerization domain containing 8
- Symbol
- kctd8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within monoatomic ion transmembrane transport and protein homooligomerization. Predicted to be part of receptor complex. Is expressed in dorsal habenular nucleus; habenula; parapineal organ; and thalamus. Orthologous to human KCTD8 (potassium channel tetramerization domain containing 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | Potassium channel tetramerisation-type BTB domain | Potassium channel tetramerization domain-containing protein 8, H1 domain | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q3L1G3 | InterPro | 280 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-369O7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194347 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194382 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037241 (1) | 1074 nt | ||
| Genomic | GenBank:BX511303 (1) | 190512 nt | ||
| Polypeptide | UniProtKB:Q3L1G3 (1) | 280 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Banerjee, B., Koner, D., Karasik, D., Saha, N. (2020) Genome-wide identification of novel long non-coding RNAs and their possible roles in hypoxic zebrafish brain. Genomics. 113(1 Pt 1):29-43
- Guglielmi, L., Bühler, A., Moro, E., Argenton, F., Poggi, L., Carl, M. (2020) Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry. Development (Cambridge, England). 147(6):
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Lekk, I., Duboc, V., Faro, A., Nicolaou, S., Blader, P., Wilson, S.W. (2019) Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry. eLIFE. 8:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Beretta, C.A., Dross, N., Guglielmi, L., Bankhead, P., Soulika, M., Gutierrez-Triana, J.A., Paolini, A., Poggi, L., Falk, J., Ryu, S., Kapsimali, M., Engel, U., Carl, M. (2017) Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Current biology : CB. 27(2):270–278
- Lagadec, R., Laguerre, L., Menuet, A., Amara, A., Rocancourt, C., Péricard, P., Godard, B.G., Celina Rodicio, M., Rodriguez-Moldes, I., Mayeur, H., Rougemont, Q., Mazan, S., Boutet, A. (2015) The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain. Nature communications. 6:6686
- deCarvalho, T.N., Subedi, A., Rock, J., Harfe, B.D., Thisse, C., Thisse, B., Halpern, M.E., Hong, E. (2014) Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (New York, N.Y. : 2000). 52(6):636-55
- Garric, L., Ronsin, B., Roussigné, M., Booton, S., Gamse, J.T., Dufourcq, P., Blader, P. (2014) Pitx2c ensures habenular asymmetry by restricting parapineal cell number. Development (Cambridge, England). 141:1572-9
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